TGFB1 and neoplasm: Notably, the transforming growth factor‐β (TGF‐β) signaling pathway regulates clathrin‐mediated endocytosis and macropinocytosis, both critical for NP uptake.[43] Additionally, interleukin‐10 may enhance LNP internalization by altering cytoplasmic organization and cell membrane fluidity.[44] Furthermore, C‐C motif chemokine ligand 18 (CCL18), a cytokine linked to tumor progression, promotes the malignant transformation of cancer cells and may also increase NP uptake.[45] A recent study by Brill–Karniely et al.