TNFSF10 and cancer: ONC201 (also known as TIC10, originally discovered in the El-Deiry Lab [11, 12] as a TRAIL-inducing compound), is a novel first-in-class small molecule imipridone compound, that has shown promise in targeting various pathways involved in cancer progression, such as the extrinsic apoptotic pathway, upregulation of pro-apoptotic TRAIL receptor DR5 [13–15].