In addition, the CXCL5/CXCR2 axis has been shown to activate the PI3K/AKT/GSK‐3β (glycogen synthase kinase‐3β)/Snail (human snail homolog (Drosophila)–like 1 protein) signaling pathway, which is involved in the EMT of HCC and significantly increases the proliferation, migration, and invasiveness of HCC cells [42]. The gene discussed is CXCR2; the disease is hepatocellular carcinoma.