Pan‐cancer analysis of TCGA datasets revealed that PCSK9 is highly expressed in several cancers, including BRCA, cervical squamous cell carcinoma, colon adenocarcinoma, esophageal carcinoma, HNSCC, HCC, rectal adenocarcinoma, gastric adenocarcinoma, thyroid carcinoma, and endometrial carcinoma, and is significantly associated with advanced disease staging and poor prognosis [192]. This evidence concerns the gene PCSK9 and hepatocellular carcinoma.