In head and neck squamous cell carcinoma (HNSCC), inhibiting SQLE through a cholesterol‐dependent mechanism decreases the affinity of Akt for lipid rafts, leading to Akt inactivation at the lipid raft level, reducing GSK‐3β phosphorylation at S9, and increasing c‐Myc phosphorylation at T58, ultimately destabilizing c‐Myc and promoting HNSCC progression [140]. The gene discussed is MYC; the disease is head and neck squamous cell carcinoma.