Through bioinformatics analysis and immunohistochemistry, it was found that NAD(P)H quinone oxidoreductase‐1 (NQO1), through the NQO1/p53/SREBP1 axis, induces the transcriptional activity of SREBP1, promoting HCC progression and metastasis [100]. The gene discussed is TP53; the disease is hepatocellular carcinoma.