AT1R activates the PI3K/AKT/NF‐κB signaling pathway to induce bc cells to upregulate VEGF to promote angiogenesis, cell proliferation, and inspire the production of adhesion molecules (such as E‐selectin) and epithelial–mesenchymal transition (EMT) to depolarize tumor cells in order to invade and migrate to adjacent tissues, affecting the progression and survival of tumor patients [25]. The gene discussed is NFKB1; the disease is neoplasm.