and Da et al., which demonstrated increased NK cell activation after ADU‐S100 treatment[38] and augmented CAR‐NK cell treatment efficacy in PDAC when combined with cGAMP.[89] While some studies illustrate a positive effect of STING agonists on NK cells and enhanced tumor cell killing upon combined treatment, others reveal a negative influence mediated by Bregs. The gene discussed is STING1; the disease is neoplasm.