A recent study showed that ENPP1 drives breast cancer growth by reducing extracellular cGAMP.[52a] The breakdown of extracellular cGAMP enhanced the concentration of adenosine in the TME, reduced immune cell infiltration, and increased metastasis in CIN tumors[53] (Figure 2). The gene discussed is ENPP1; the disease is cervical squamous intraepithelial neoplasia.