Nevertheless, those modifications do not lead to a complete absence of STING as mutations in the CGAS or TMEM173, the STING encoding gene, are rare (0.5–0.6%) in CIN tumors.[54] Therefore, inhibitors of DNA methylations or ENPP1 might be beneficial co‐stars to improve the STING‐related anti‐tumor response. This evidence concerns the gene ENPP1 and cervical squamous intraepithelial neoplasia.