NFKB1 and neoplasm: As mentioned in section 4, DMXAA could only recognize murine STING.[90] Recently, it was demonstrated that DMXAA functions as a partial STING agonist, performing a more suppressive effect on the STING‐IRF3 axis than on the NF‐κB axis.[60] Since NC NF‐κB activation through STING has been linked to immunosuppressive effects and mediating tumor growth, this could potentially explain the lack of effectiveness observed in clinical trials.