Q‐Alb is positively correlated with age84 and is elevated in MCI,11 patients with vascular risk factors85, and several other neurodegenerative diseases such as Lewy body dementia (LBD), AD, Parkinson's disease, and vascular dementia (VAD),10, 86, 87, 88, 89 highlighting BBB dysfunction as a common mechanism in human aging, cognitive decline, and dementia. This evidence concerns the gene ALB and Alzheimer disease.