Despite these associations between Q‐Alb and neurodegenerative diseases, a recent study found no direct association between Q‐Alb and amyloid‐PET or APOE genotype, suggesting that this increase in Q‐Alb may occur independently of AD pathology or be reflective of BBB physiology less related to certain types/stages of neurodegeneration.10 Here, APOE is linked to Alzheimer disease.