NPM1 and cancer: For instance, the export protein XPO1 is overexpressed in various cancers and is associated with disease progression, treatment resistance, and poorer survival by promoting the cytoplasmic localization of regulatory proteins such as the tumor suppressor p53, CDK1, APC, BRCA1, BRCA2, survivin, nucleophosmin (NPM), and members of the forkhead box family of transcription factors [8, 19].