The HMGB1/RAGE/IL‐8 axis plays a crucial role in neutrophil recruitment into the TME and NETosis as HMGB1 was found to bind the RAGE receptor on glioma cells, activating NF‐κB and upregulating IL‐8 expression—an influential neutrophil chemoattractant [50]. The gene discussed is CXCL8; the disease is glioma.