Infiltration of lymphocytes (CD3+ or CD8+) and macrophages (CD68+ or CD163+) and expression of PD‐1/PD‐L1 were more pronounced in poorly differentiated neuroendocrine carcinoma compared to well‐differentiated neuroendocrine tumors, while CD68 and PD‐L1 correlated with advanced disease stage. This evidence concerns the gene CD274 and neuroendocrine carcinoma.