The HMGB1/RAGE/IL‐8 axis plays a crucial role in neutrophil recruitment into the TME and NETosis as HMGB1 was found to bind the RAGE receptor on glioma cells, activating NF‐κB and upregulating IL‐8 expression—an influential neutrophil chemoattractant [50]. This evidence concerns the gene CXCL8 and central nervous system cancer.