MAPT and tauopathy: 122). Additionally, vascularized brain assembloids showed accelerated maturation of astrocytes, high numbers of synapses, as well as improved proliferation of neuroepithelial cells when compared to organoids (Ref. 123). Besides, elevated levels of total tau and phosphorylated tau, among others, were reported in the following assembloids harbouring the tau301S mutation, highlighting their significance in the study of tauopathies (Ref. 123).