TTN and cardiomyopathy, familial restrictive, 1: Common etiologies include amyloidosis, storage disorders (Anderson-Fabry disease, Pompe disease, hemochromatosis) mutations in cardiac proteins (sarcomeric, cytoskeletal, envelope, titin), radiation-induced, medication-induced, and undifferentiated RCM.1, 2, 3 Appropriate diagnosis can remain elusive and present late in the disease course, as such the prognosis of RCM regardless of cause is very poor and many patients progress to end-stage heart failure.4, 5 Emerging therapies have impacted some types of RCM, but ultimately end-stage RCM can only be cured through cardiac transplantation.