◼ A systematic review and meta-analysis of 12 studies (1 RCT, 11 cohort studies) showed that TCZ resulted in significant improvement in CAS, proptosis, diplopia, and TSH-R-Ab levels in patients with glucocorticoid resistant active moderate-to-severe GO◼ Common side effects: mild neutropenia, hypercholesterolemia, transient rise in liver enzymes. Here, TSHR is linked to Decreased total neutrophil count.