In a retrospective posthoc analysis of the Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension (ASA-STAT), Al-Naamani et al found that at baseline, lower total cholesterol and von Willebrand factor (vWF) levels, as well as higher plasma NT-proBNP, were predictors of death or lung transplantation, after adjustment for age, sex, PAH etiology, and 6MWD.55 The gene discussed is VWF; the disease is pulmonary arterial hypertension.