Interestingly, in a recent study by Omura et al, long noncoding RNA H19 appeared to be a marker of maladaptive right ventricular coupling, differentiating controls with normal right ventricular function from IPAH, as well as IPAH with the decompensated right ventricle phenotype vs the compensated ditto.67 Here, H19 is linked to idiopathic pulmonary arterial hypertension.