In a follow-up study of the ASA-STAT trial, Matura et al found that the inflammatory markers interleukin-6 and tumor necrosis factor-α (TNF-α) were associated with the Medical Outcomes Study Short Form-36 score and its subscales comprising pain, vitality, and mental health (anxiety/depression) at baseline and the 3-month follow-up.65 The gene discussed is TNF; the disease is major depressive disorder.