IFNG and encephalomyelitis: Indeed, one could term those states as inflammatory OLs opening the gate to the idea that these cells may become immunocompetent under certain conditions (e.g., encephalomyelitis and upon IFN-γ exposure) as they may express MHC-I and –II genes and thus, contribute to neuroinflammation and neurodegeneration (Castelo-Branco et al., 2024; Kirby and Castelo-Branco, 2021).