For other thrombogenic factors, such as non‐criteria APS with anti‐CLβ2GP1 complex, anti‐PEIgM, anti‐PS/PT antibodies, protein S deficiency, factor XII deficiency and increased platelet aggregation, the first LDA treatment did not improve the live birth rates (Table 3). The gene discussed is PROS1; the disease is autoimmune polyendocrinopathy.