Among them, GAD1 exhibited the strongest connection to CESD8 (“Felt lonely”) within the depression community (edge = 0.075); GAD3 showed the strongest connection to CESD4 (“Feeling increasingly exhausted and useless with age”) within the depression community (edge = 0.029); and CESD3 was most strongly linked to GAD6 (“Becoming easily annoyed or irritable “) within the anxiety community (edge = 0.040). The gene discussed is GAD1; the disease is depressive symptom measurement.