Dysregulation of the RAS can contribute significantly to the pathogenesis of various cardiovascular disorders (1–4) Within the RAS, the angiotensin II (Ang-II)/angiotensin II receptor type 1 (AT1R) axis is critical for regulating blood pressure and influencing the development of cardiac hypertrophy and fibrosis (2, 5). This evidence concerns the gene AGTR1 and cardiac hypertrophy.