Ang 1-7 also exhibits strong anti-inflammatory and anti-fibrotic properties, playing a crucial role in mitigating cardiac remodeling, hypertrophy, and fibrosis associated with hypertension and heart failure, and reduces thrombosis and vascular calcification demonstrating protective effects against atherosclerosis and aneurysm formation in preclinical models (85, 86). This evidence concerns the gene ANGPT1 and heart failure.