The immunohistochemistry with an antibody against phosphorylated tau-labeled (globoid) tangles and numerous glial inclusions predominantly as tufted astrocytes and, less commonly, as coiled bodies (Figures 4C–G), allowing for the diagnosis of frontotemporal lobe degeneration (FTLD)-tau with PSP-subtype pathology (Mackenzie et al., 2010). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.