Model 3 comprised stone density (p < 0.001, OR = 5.96, 95%CI = 3.01–11.81), operation time (p = 0.005, OR = 2.26, 95%CI = 1.28–4.00), hydronephrosis (p < 0.001, OR = 0.37, 95%CI = 0.22–0.62), urine detection for bacteria (p = 0.003, OR = 2.13, 95%CI = 1.30–3.48), and the percentage of Tph cell (p < 0.001, OR = 0.39, 95%CI = 0.27–0.55) (Table 4). This evidence concerns the gene TPH1 and hydronephrosis.