Lastly, Model 4 included stone density (p < 0.001, OR = 5.63, 95%CI = 2.87–11.05), hydronephrosis (p < 0.001, OR = 0.35, 95%CI = 0.21–0.58), urine nitrite (p = 0.044, OR = 2.04, 95%CI = 1.02–4.07), urine leukocytes (p = 0.049, OR = 1.77, 95%CI = 1.00–3.13), and the percentage of Tph cell (p < 0.001, OR = 0.37, 95%CI = 0.26–0.52) (Table 4). The gene discussed is TPH1; the disease is hydronephrosis.