In the most cited literature, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Palmer et al. identified two gene mutations (R510X and 2282del4) significantly associated with AD through genotyping both affected individuals and healthy controls, leading to the identification of filaggrin loss-of-function alleles. This evidence concerns the gene FLG and atopic eczema.