PCSK9 and atherosclerosis: In particular, the evaluation of surrogate and prognostic markers of CV risk pointed out a possible correlation between arterial stiffness measured by pulse wave velocity (PWV) and atherosclerosis (19) considering the analogous underlying mechanisms in plaque formation and arterial stiffening, PCSK9 accumulation in atherosclerotic plaques could also be associated with arterial wall remodeling (20).