SERPINA1 and lung disorder: Treatment can include AAT augmentation therapy, in which a patient receives weekly infusions of AAT antiprotease from pooled plasma to achieve normal plasma levels and slow disease progression.3, 4 While AAT antiprotease augmentation therapy can slow lung damage and ameliorate serum abnormalities, some patients continue to progress to end-stage lung disease due to emphysematous changes and require lung transplantation (LT).5