Although miR-124 has been poorly explored in AD, there are consistent lines of evidence, supporting its critical role in APP transcription and alternative splicing (Smith et al., 2011; Garcia et al., 2021), BACE1 expression (Fang et al., 2012; An et al., 2017), and tau hyperphosphorylation (Kang et al., 2017; Hou et al., 2020). Here, APP is linked to Alzheimer disease.