AGER and Alzheimer disease: Indeed, AD astrocytes showed a significant upregulation of the genes S100B (p < 0.001 vs. control), AGER (encoding the advanced glycosylation end-product-specific receptor, p < 0.05 vs. control), GFAP (p < 0.05 vs. control), and GJA1 (encoding gap junction protein alpha 1, p < 0.05 vs. control).