We hypothesize that this may be due to the higher proliferative activity and increased expression of infiltrating lymphocytes in tumor cells, which are more readily recognized and eliminated by the immune system, particularly the abundant anti-tumor immune cells within the infiltrating lymphocytes, such as CD4+ T cells and CD8+ T cells (Zhang et al., 2021; Sun et al., 2022). This evidence concerns the gene CD8A and neoplasm.