TRAF2 and cancer: Therefore, TRAF2 is involved in a variety of cancer-related cellular processes, including activation of the NFκB signaling pathway (Wang Z. et al., 2024), stimulation of MAPKs signaling cascade transactivation (Shi and Sun, 2018), triggering ROS/endoplasmic reticulum (ER) stress signaling (Zhao et al., 2021), regulation of autophagy and apoptosis (Deen et al., 2024; Xu et al., 2023; Jiang et al., 2024), and control of cellular senescence (Yao et al., 2024).