ATL-1 from AMK  • Inhibited cell proliferation, migration, and invasion• Downregulated PDK1 and inhibited FoxO1 phosphorylation• Decreased Bcl-2 and increased Bax expression• Decreased MMP2 and vimentin and increased E-cadherin expression• ATL-1 inhibited the malignant development of cancer cells and increased oxaliplatin sensitivity by decreasing PDK1 and inhibiting FoxO1 phosphorylation. The gene discussed is CDH1; the disease is cancer.