AMK, especially honey-bran-fried AMK  • Decreased the ulcer index and ulcer area• Increased levels of SOD and GSH-Px• Reduced the MDA, IL-1β, IL-6, TNF-α, IL-1β, MMP-9, TIMP-1, NF-κB-protein levels• Regulated extracellular matrix degradation• Normalized intestinal floraAnti-ulcer and anti-inflammatory effect of AMK is related to NF-κB-MMP-9/TIMP-1 signaling pathway. This evidence concerns the gene SOD1 and ulcer disease.