ATL-2 from AMK  • Inhibited proliferation and induced apoptosis• Reduced cell motility• Downregulated p-Akt and p-ERK• Increased Bax/Bcl-2 ratio• ATL-2 exerted significant anti-tumor effects on the gastric carcinoma cells by modulating Akt/ERK signaling pathway. This evidence concerns the gene BCL2 and gastric carcinoma.