AMK polysaccharide  • Enhanced phagocytosis by BMDMs• Activated expression and secretion of immunomodulatory factors (IL-6, IFN-λ, TNF-α, and NO) in BMDMs through TLR4 and MyD88The TLR4/MyD88 pathway plays a vital role in anti-cancer effects of AMK. The gene discussed is TNF; the disease is cancer.