Atractylochromene from AMK  • Inhibited β-catenin nuclear translocation• Decreased levels of cyclin D1, target gene of β-catenin, and galectin-3, and β-catenin nuclear translocation modulator• Suppressed cell viability• Atractylochromene inhibits the Wnt/β-catenin signaling pathway through modulation of the nuclear translocation of β-catenin and galectin-3 in colon cancer cells. The gene discussed is LGALS3; the disease is colonic neoplasm.