MAPK8 and gastric cancer: AMK extract  • Reduced AGS cell growth• Increased cell cycle sub-G1 phase• Induced apoptosis via ROS generation• Upregulated mitochondrial depolarization and reduced TMRM-positive fluorescence• Increased cleavage of pro-Caspase-9, PARP, and caspase-3• Altered Bax/Bcl-2 ratio and reduced the level of Bcl-2 and Bcl-xL levels• Increased p38 and JNK phosphorylation and reduced the phosphorylation levels of ERK and AKT• Inhibited cell migrationAMK extract induced apoptosis in gastric cancer cell through intrinsic mitochondrial pathway.