LJT extract and its component chlorogenic acid  • Decreased the DAI score, reduced colon mucosal injury, and inhibited colon length shortening• Reduced the serum IL-1β levels and increased colonic SOD, catalase activity, and serum GSH levels• Elevated the expression of Nrf2 and decreased TNF-α• Improved gut microbiota diversity and fecal SFCA productionFMT of LJT-mediated gut microbiota alleviated disease symptoms of colitis. The gene discussed is NFE2L2; the disease is colitis.