Chen et al. reported that diregulin induces cartilage destruction in osteoarthritis by activating the EGFR/PI3K/AKT pathway (Chen et al., 2014), while AlaaeldinR et al. demonstrated that fatty acid glucoside inhibits inflammation by suppressing the EGFR/PI3K/AKT pathway (Alaaeldin et al., 2022). The gene discussed is EGFR; the disease is osteoarthritis.