TNFRSF10B and systemic lupus erythematosus: DR5 agonists regulate apoptosis and immunomodulation in SLE, (Hilliard et al., 2001; Song et al., 2000; Ichikawa et al., 2003), with Lamhamedi-Cherradi SE et al. (Lamhamedi-Cherradi et al., 2003; Liu et al., 2003) finding that DR5 activation reduced inflammation and organ damage in a mouse model of SLE.