MacFarlane et al. had revealed that TRAIL signals to apoptosis were predominantly transmitted via DR4 in chronic lymphocytic leukemia cells as well as pancreatic carcinoma cells (Stadel et al., 2010; MacFarlane et al., 2005a; Natoni et al., 2007; MacFarlane et al., 2005b), Micheau et al. reported that DR4 as a master player of apoptosis induced by TRAIL and ER stress (Dufour et al., 2016). The gene discussed is TNFRSF10A; the disease is B-cell chronic lymphocytic leukemia.