CASP8 and neoplasm: In clinical phase I trials, a fully human monoclonal agonistic antibody (IgG1) specific to DR5, prevalent across various tumor types, swiftly triggers caspase-8 activation leading to apoptosis (Spierings et al., 2003; Maduro et al., 2009; Ganten et al., 2009; Leithner et al., 2009; McCarthy et al., 2005; Kaplan-Lefko et al., 2010)