Meanwhile, more studies had shown that DR5 probably played a major role in the initiation of apoptosis (Ichikawa et al., 2001; Nahacka et al., 2018) and showed better potential for antitumor drug development, for the basis phenomenon that DR5 exhibits high levels of expression in plenty types of cancer cell lines while expressed very low expression in normal tissues, which indicates the potential safety advantage for tumor targeted therapy, and for that DR5 contains the highest affinity to TRAIL at the optimal human body temperature of 37°C (Truneh et al., 2000). The gene discussed is TNFRSF10B; the disease is cancer.