TRPV1, a non-selective ligand-gated cation channel with high calcium permeability, is activated by various stimuli, including low pH, extreme heat, and vanilloids (Szallasi et al., 2007). The agent DWP05195 induces apoptosis in human ovarian cancer cells by activating endoplasmic reticulum stress via the ROS-p38-CHOP pathway (Wang et al., 2020a). The gene discussed is TRPV1; the disease is ovarian cancer.