TNF and psoriasis: This study found that luteolin and luteolin derivatives can down-regulate the expressions of inflammatory factors such as IL-6 and TNF-α, can also increase the activity of SOD enzyme and the content of GSH in the skin tissue induced by imiquimod, and at the same time can reduce the content of MDA, further inhibit the release of free radicals, thereby enhancing the body’s anti-inflammatory and antioxidant abilities and having the effect of treating psoriasis.