NOTCH1 and head and neck squamous cell carcinoma: For example, FBW7, an E3 ubiquitin ligase, interacts with SNX5 to reduce the ubiquitination and degradation of cancer-associated proteins such as c-Myc, NOTCH1, and Cyclin E1, thereby promoting the progression of head and neck squamous cell carcinoma (HNSCC) (Figure 4A) (Cai et al., 2019).