For example, FBW7, an E3 ubiquitin ligase, interacts with SNX5 to reduce the ubiquitination and degradation of cancer-associated proteins such as c-Myc, NOTCH1, and Cyclin E1, thereby promoting the progression of head and neck squamous cell carcinoma (HNSCC) (Figure 4A) (Cai et al., 2019). Here, CCNE1 is linked to head and neck squamous cell carcinoma.