TRPV4 and lip and oral cavity carcinoma: We cannot rule out a contribution of TRPV4 expressed in neurons to oral cancer pain; however, clinical experience finds that oral cancer pain is not alleviated by NSAIDs, anti-inflammatory drugs commonly used to treat temporomandibular joint pain (48), for example, suggesting the etiology of oral cancer pain differs from painful conditions associated with inflammation and upregulation of neuronal TRPV4.