CLOCK and Parkinson disease: Additionally, the right half of Figure 4 contains the annotationthat resulted from our work with experimental data on anage-related growth of bone fragility in mice concurrently witha decrease in the expression levels of the mouse gene Clock(Kaya et al., 2022) in terms of a decrease in the expressionlevels of BMAL1, a human paralog to Clock, according to theGeneCards database (Stelzer et al., 2016), in the followingage-related human diseases: cancer (Elshazley et al., 2012),circadian rhythm disorder and Parkinson’s disease (Dinget al., 2011).