CLOCK and gastroenteritis: As can be seen from Figure 4, a decrease in expressionlevels of a human CLOCK gene homologous to the mouseClock gene was observed in patients with intestinal inflammation(Giebfried, Lorentz, 2023), circadian rhythm disorder(Oishi et al., 2005; Roybal et al., 2007), obstructive pulmonarydisease and cellular senescence (Li L. et al., 2022), which areage-related disorders (Jacenik et al., 2019; Li Z. et al., 2021;Neba Ambe et al., 2022; Siniscalchi et al., 2024).