Since the receptors of TLR1, 2, 4, 5, 6 and 10 belongto surface membrane receptors that recognize mainly lipidcomponents of bacterial structures, and TLR3, 7, 8 and 9are expressed on the membranes of intracellular organelles,ligands for which are components of nucleic acids of viruses(Akira et al., 2001; Sameer, Nissar, 2021), an increase in thefrequency of a number of TLR gene genotypes in a group ofpatients may indirectly indicate the involvement of infectiousfactors in the initiation of POAG. The gene discussed is TLR1; the disease is open-angle glaucoma.