The aim of our research is to analyze the associationof TLR2 (rs5743708), TLR3 (rs3775291), TLR4 (rs4986790,rs4986791), TLR6 (rs5743810) gene polymorphisms withprimary open-angle glaucoma in patients of Western Siberia. Here, TLR4 is linked to open-angle glaucoma.