Key molecular players, including tumor protein p53 (TP53), signal transducer and activator of transcription 3 (STAT3), AKT serine/threonine kinase 1 (AKT1), and interleukin-6 (IL6), are known to contribute to neurodegeneration in AD and tumorigenesis in GBM. The gene discussed is STAT3; the disease is Alzheimer disease.