EGFR and neoplasm: The most effective adjuvant treatments for patients with CRC are radiotherapy; chemotherapy regimens composed of 5-fluorouracil, oxaliplatin, and irinotecan; targeted agents such as anti-angiogenic compounds (bevacizumab or aflibercept) or anti-epidermal growth factor receptor (EGFR) drugs (cetuximab or panitumumab) according to the RAS/BRAF status of the tumor; and immunotherapy according to mismatch repair (MMR) alterations and microsatellite status (9).