SCRIB and neoplasm: Three epithelial polarity proteins, Lethal giant larvae (Lgl), Scribble (Scrib) and Discs large (Dlg) are established tumor suppressors that, if lost homozygous throughout an entire imaginal epithelium, can cause uncontrolled proliferation and amorphous overgrowth (Gateff, 1978; Bilder et al., 2000; Brumby and Richardson, 2003).