FLCN and Birt-Hogg-Dube syndrome: Laura S’s research identified that germline mutations on chromosome 17 in the FLCN gene are responsible for Birt-Hogg-Dubé syndrome, with BHD-associated renal tumors displaying inactivation of the wild-type FLCN allele due to somatic mutations or chromosomal loss, thus confirming FLCN as a tumor suppressor gene consistent with the classic two-hit model.