We have compiled a timeline of key milestone developments in mitochondrial diseases, cardiovascular diseases, and skeletal muscle disorders where Fnip1 signaling has been implicated, as shown in Figure 1 (Baba et al., 2006; Baba et al., 2012; Dai et al., 2024; Dunlop et al., 2014; Hasumi et al., 2008; Linehan, Srinivasan and Schmidt, 2010; Manford et al., 2021; Manford et al., 2020; Meng and Ferguson, 2018; Petit et al., 2013; Reyes et al., 2015; Rezvan et al., 2024; Siggs et al., 2016; Sun et al., 2023; Takagi et al., 2008; Xiao et al., 2024; Yin et al., 2022; Zhang et al., 2012). The gene discussed is FNIP1; the disease is mitochondrial disease.