FLCN deficiency promoted STAT2 recruitment to chromatin and decelerated cell proliferation, underscoring the FLCN and FNIP1/FNIP2 complex’s distinctive role in the development of human renal tumors and identifying potential prognostic biomarkers (Figure 6D) (Rallis et al., 2013; Schmidt and Linehan, 2018). This evidence concerns the gene FLCN and kidney neoplasm.