In addition, US7–US9 genes have been reported to affect the innate response to HCMV infection by targeting Toll-like receptors (TLRs), the Mitochondrial Antiviral-Signalling Protein (MAVS) and the Stimulators of Interferon Genes (STING)-mediated signaling pathways [14,15]. This evidence concerns the gene MAVS and cytomegalovirus infection.