C3 and viral infectious disease: Interestingly, although robust predicted binding sites were identified in the C1 ORF and C4-C1 overlapping region as targets of consensus ghr-miRNAs that may feasibly inhibit CLCuKoV-Bur replication, no such consensus ghr-miRNAs were identified in the CLCuKoV-Bur C3 or V1 ORFs, even though the latter genes are likewise indispensable for virus infections (Figure 8).