In this prospective study, we aimed to assess the seroprevalence of IgM/IgG against SARS-CoV-2 among newcomer students from Kafr Elsheikh University, Egypt, compare the results of non-vaccinated group with a cross matched vaccinated group, and correlate the results to participants’ anthropometrics, relevant COVID-19 history, and lifestyle. The gene discussed is CD40LG; the disease is COVID-19.