These differences can be explained by differences in the DNA integration point of HPV (8q24.21 is integrated in adenocarcinoma, while 21p11.2 is integrated in squamous carcinoma), the involvement of different genomic areas (dysregulation of oncogenes such as STARD3 and ERBB2 is observed in adenocarcinoma, while expression of viral oncogenes is increased in aquatic carcinoma), and different molecular signatures (squamous carcinoma is associated with keratinization and glucose metabolism pathways, while adenocarcinoma uses different oncogenic pathways) [14,20]. Here, ERBB2 is linked to adenocarcinoma.