Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration [61,62,63] In this context, there are data suggesting that the involvement of the IL-22R1/IL-22 axis could be protective at the beginning of SARS-CoV-2 infection but could shift to a detrimental response over time and therefore predict disease severity [64,65]. The gene discussed is IL22RA1; the disease is viral infectious disease.