An 8-week experimental model of ulcerative colitis-related local and systemic injury in hairless mice exposed to UV-irradiation revealed the ability of β-carotene to decrease an elevated degree of peroxidized cholesterol in the skin and matrix metallopeptidase 9 suppression and activity, along with the occurrence of wrinkles and sagging skin [117]. The gene discussed is MMP9; the disease is ulcerative colitis.