As a key antioxidant axis, the NRF2/HO-1/GPX4 pathway not only protects against skin aging and damage caused by ultraviolet radiation [34] but also plays a broad role in diseases such as Parkinson’s disease [35], periodontitis [36], and non-alcoholic fatty liver disease [37]. This evidence concerns the gene GPX4 and metabolic dysfunction-associated steatotic liver disease.