MMP2 and Myocardial fibrosis: Dapagliflozin reduced interstitial fibrosis in mice after MI as well as reducing the expression of collagen 2 (Col2), collagen 3 (Col3), matrix metalloproteinase 2 (Mmp2) and 9 (Mmp9) at the mRNA level; reduced myocardial fibrosis and the protein expression of collagens 1 and 3 in a rabbit model of HFrEF induced by aortic stenosis [43]; and achieved the same in a mouse model of arrhythmogenic cardiomyopathy [24] as well as in a diabetic rabbit model [23].