STAT3 and autoimmune myocarditis: In a mouse model of experimental autoimmune myocarditis, empagliflozin was shown to protect cardiomyocytes from pyroptosis through NF-κB inhibition [38] and reduce inflammatory response by favoring M2 macrophage differentiation, which was associated with the inhibition of Signal Transducer and Activator of Transcription 3 (STAT3)T activation [62].