The immune system plays a pivotal role in psoriasis, with cytokines such as tumour necrosis factor alpha (TNF-α), interleukin (IL) -6, IL-8, IL-17, IL-22, IL-23, and RANTES (Regulated upon activation, normal T Cell expressed and presumably secreted) being central to the inflammatory processes observed in the disease [4,5]. The gene discussed is IL37; the disease is psoriasis.