TLR4 and cardiovascular disorder: Many scholars have investigated the protective effects of natural drugs against pyroptosis and found that numerous traditional Chinese medicines aim to inhibit NLRP3 inflammasome activation and caspase-1 activity to treat cardiovascular diseases, regulating associated upstream pathway proteins, such as PI3K-AKT, AMPK, TLR4, or NF-κB [39,40,41,42].