Although there were no obvious changes in body weight, food intake, and blood glucose at 2, 3, and 4 months after treatment (Figure 6A–E), the results definitely showed that 4 months of both NMN2 and NR2 treatments also aggravated atherosclerosis in HFD-fed ApoE−/− mice (Figure 7A–F). Here, APOE is linked to atherosclerosis.