TGFB1 and Hepatic fibrosis: The TGF-β1 grayscale values and PDGF positivity in the saline group were much greater than those in the healthy group, while after treatment with IM-CS NPs, the levels of TGF-β1 and PDGF were reduced, indicating that IM-CS NPs can reduce the activation of HSCs by inhibiting the secretion of TGF-β1 and PGDF, thus exerting good anti-liver fibrosis efficacy.