Cheng et al. used ansamitocin P3 (AP3), gold nanoclusters (AuNCs), and anti-programmed cell death-ligand1 (anti-PD-L1) to research and develop the multifunctional gold nanocapsule AP3-AuNCs-anti-PD-L1 for the treatment of hepatocellular carcinoma. This evidence concerns the gene CD274 and hepatocellular carcinoma.